NFL Week 4 Odds: Best Bets and Predictions
This NFL Week 4 odds: best bets and predictions guide rounds up the full slate from Thursday night through Monday, with the Ravens laying the week's biggest number at home against Tennessee and the Colts and Commanders taking their rivalry across the Atlantic to London. After three straight weeks of favourites losing outright, this is a card worth approaching with a little extra caution rather than assuming the short prices are safe.
NFL Week 4 Odds: Full Schedule and Lines
All times below are ET; lines are current as of midweek and will keep moving into the weekend, so treat these as a guide rather than the final word. low you'll find every spread, moneyline, and total, a handful of spots worth a second look, and pointers for comparing markets before you check sportsbet.io's live NFL odds yourself.
Thursday, October 1
- Steelers @ Browns — Steelers -2.5, ML Steelers -155 / Browns +130, O/U 38.5
Sunday, October 4
- Colts @ Commanders (Tottenham Stadium, London) — Colts -3.5, ML Colts -180 / Commanders +150, O/U 47.5
- Cardinals @ Giants — Giants -1.5, ML even on both sides, O/U 44.5
- Cowboys @ Texans — Texans -2.5, ML Cowboys +125 / Texans -150, O/U 47.5
- Packers @ Buccaneers — Packers -3.5, ML Packers -190 / Buccaneers +160, O/U 39.5
- Jaguars @ Bengals — Bengals -2.5, ML Jaguars +125 / Bengals -150, O/U 51.5
- Rams @ Eagles — Rams -1.5, ML Rams -130 / Eagles +110, O/U 46.5
- Patriots @ Bills — Bills -7, ML Patriots +250 / Bills -310, O/U 48.5
- Jets @ Bears — Bears -3, ML Jets +135 / Bears -160, O/U 42.5
- Titans @ Ravens — Ravens -11.5, ML Titans +475 / Ravens -650, O/U 43.5
- Dolphins @ Vikings — Vikings -10, ML Dolphins +400 / Vikings -550, O/U 38.5
- Broncos @ 49ers — 49ers -2.5, ML Broncos +130 / 49ers -155, O/U 46.5
- Chiefs @ Raiders — Chiefs -4.5, ML Chiefs -225 / Raiders +185, O/U 48.5
- Chargers @ Seahawks — Seahawks -6.5, ML Chargers +250 / Seahawks -310, O/U 43.5
- Lions @ Panthers — Lions -3.5, ML Lions -190 / Panthers +160, O/U 50.5
Monday, October 5
- Falcons @ Saints — Saints -2.5, ML Falcons +130 / Saints -155, O/U 48.5
Lines shift fastest around injury news, so it's worth a last check on sportsbet.io's upcoming fixtures page closer to kickoff rather than locking in a bet off a midweek number.
Best Bets for NFL Week 4
Three straight weeks of upsets make this the hardest card of the season to call with confidence, but here's where the numbers look most worth a second look.
Ravens -11.5: The Week's Biggest Number
Baltimore's double-digit home favourite status against Tennessee makes this the most lopsided line on the board, with a moneyline near -650 offering little back for the risk. If you like the Ravens here, the spread gives far better value than laying that kind of price outright, especially given how often short-priced favourites have been caught out already this season.
Colts @ Commanders: A Genuine Neutral-Site Wildcard
This London fixture adds travel and unfamiliar conditions to an already competitive AFC-NFC crossover, and games played away from either team's home stadium have a track record of defying the market more often than a standard Sunday fixture. Check the in-play hub once the game gets underway to see how the line moves in response to the occasion.
Rams @ Eagles: Tight Line, Model Disagreement
Los Angeles are favoured by just 1.5 points on the road, but several computer models have flagged Philadelphia as a value side here despite the Rams' market edge. A line this close is exactly the kind of spot where shopping for the best number on either side matters more than picking a side off reputation alone.
Broncos @ 49ers: Another Close Call Worth Watching
San Francisco are modest 2.5-point favourites at home, but Denver has been competitive enough on the road that some models are backing the Broncos to cover or even win outright. Sportsbet.io's sports betting hub breaks down how moneyline and spread markets are typically priced if you want to understand why a short favourite like this can still carry real underdog value.
Bills -7: Respect the Number, Check the Price
Buffalo have been one of the more reliable home favourites so far this season, and a 7-point line against New England looks fair on paper. Still, with the moneyline sitting near -310, the spread remains the more balanced way into this one rather than laying a short price outright.
How to Approach NFL Week 4 Lines After Three Weeks of Upsets
With favourites losing outright in each of the first three weeks, the sharper approach this week is treating every short price with a little more scepticism than usual. Compare the same market across books rather than betting the first number you see, weigh current health and travel situations above reputation, and remember that a lopsided spread doesn't guarantee a lopsided game this early in the season. Check sportsbet.io's upcoming fixtures page for the latest lines as Sunday approaches.
Betting Responsibly Through the NFL Season
A week with the season's biggest spread so far and a neutral-site game in London can tempt bigger swings than a normal week. Treat every result above as one opinion among many, not a signal to change your whole approach, and set your budget for the week's card before Thursday's kickoff rather than adjusting it as Sunday's results come in.
Account tools such as deposit limits, loss limits, and time-outs help keep a full week of NFL action within the budget you set for it — sportsbet.io's responsible gambling page lists how to set these up. Betting should stay entertainment across a 17-game season, not a way to chase back a loss from an earlier week.
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FAQs: NFL Week 4 Odds
Is there an NFL game being played in London in Week 4?
Yes. The Colts face the Commanders at Tottenham Hotspur Stadium in London on Sunday, with Washington listed as the home team despite the neutral venue.
What's the biggest favourite in NFL Week 4?
The Baltimore Ravens are 11.5-point favourites over the Tennessee Titans, the largest spread on this week's board.
Have favourites struggled against the spread so far this season?
Yes. Each of the first three weeks has produced multiple favourites losing outright, making Week 4 a card worth approaching cautiously rather than assuming short prices are safe.
Which Week 4 game has the closest spread?
Rams @ Eagles and Cardinals @ Giants are among the tightest lines on the board at around 1.5 points, making them two of the more genuinely competitive matchups of the week.
